Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming

Summary: Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) involves the reactivation of endogenous pluripotency genes and global DNA demethylation, but temporal resolution of these events using existing markers is limited.Here, we generate murine transgenic lines harboring 12n/1200 wella reporters for the 5-methylcytosine diox

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THE SPREAD OF CHRISTIANITY AMONG THE POPULATION OF THE KALMYK STEPPE OF ASTRAKHAN PROVINCE IN THE LAST THIRD OF XVII-XVIII CENTURIES

The formation of a multi-ethnic state demanded from the Russian authorities a policy that would ensure the integration of the peoples into its constituent states, the dominance of centripetal tendencies, and the strength of its state unity.The Christianization of foreigners, including Kalmyks, was considered one of the important means of achieving

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Parenting Challenges and Reasons for Not Availing Rehabilitation Services Among Families of Adolescents with Autism Spectrum Disorder: A Qualitative Study

Background: Autism spectrum disorder (ASD) is a lifelong condition requiring continued rehabilitation services.However, children with ASD who seek rehabilitation services tend to drop out once they enter puberty, because of varying reasons, some of which are unknown.This study intended to explore the reasons for not availing of rehabilitation servi

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